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KMID : 0861020210360020011
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Korea Journal of Herbology
2021 Volume.36 No. 2 p.11 ~ p.17
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Effects of Akebia quinata extract on alcohol-induced damage of liver, spleen and thymus in rats
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Lee Ji-Hye
Seo Bu-Il
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Abstract
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Objective : This study was conducted to investigate the effects of Effects of Akebia quinata (AQ) extract on alcohol-induced damage of liver, spleen and thymus in rats.
Method : Experimental animals were divided in to 4 groups; Normal group, Alcohol group, AQ50 group and AQ200 group. All rats, except for Normal group, were fed 25 % ethanol for 55 days. During experimental period, Normal group and Alcohol group were administrated saline, and AQ50 group and AQ200 group were administrated AQ extract at dose of 50 and 200 ㎎/㎏/day, respectively. We measured organ weight, liver triglyceride contents, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and triglycerid levels in serum. Also, we conducted histomorphometry and histopathological observation of liver, spleen and thymus.
Results : AQ significantly decreased the level of AST, ALT and triglyceride in serum and the liver triglyceride contents induced by ethanol. Also, AQ significantly inhibited lipid droplets accumulation in hepatocytes. The decreased relative organ weight of spleen and thymus by ethanol were increased by AQ administration. In histopathological analysis of spleen, the rats administrated AQ 200 ㎎/㎏ presented significantly increased mean diameters of white pulps, numbers of white pulps and splenic thicknesses. The administration of 200 ㎎/㎏ AQ improved decreased lobular thickness and cortex thickness of thymus, which were decreased by ethanol.
Conclusions : The results of present study indicated that AQ has an ameliorating effect for fatty degeneration of liver and damage of spleen and thymus.
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KEYWORD
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Akebia quinata, Akebiae Caulis, Alcohol, Hepatic steatosis, spleen, thymus
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